欧美医界谈断食法防治“新冠”（20230110）
1）《间歇性禁食在预防和改善COVID-19临床结果方面是否有作用？炎症、mTOR通路、自噬和卡路里限制之间的交叉（马丁·格诺尼）》（美国国立生物技术信息中心2021-06-04）
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177033/
（文章摘要）2019年冠状病毒病（COVID-19）大流行正在引发全球公共卫生危机。尽管学术界正在大力寻求新疗法，但在COVID 19的管理方面仍然没有“游戏规则改变者”。雷帕霉素的哺乳动物靶标（mTOR）是一种古老的信号系统，已被提出作为冠状病毒和其他RNA和DNA病毒使用的分子工具，以便在宿主细胞中复制和存活。近年来，间歇性禁食（IF），一种长时间严格限制卡路里的做法，由于其在多个健康系统和调节炎症方面的潜在益处而广受欢迎。IF抑制mTOR通路，类似于雷帕霉素在某些动物模型中的作用。mTOR抑制和促进自噬可能是IF在COVID-19中可能直接益处之间的关系，原因是病毒周期（蛋白质合成）中断。此外，IF在之前的多项研究中已被证明具有很强的抗炎作用，并且可能在减轻COVID -19严重程度方面发挥作用。本综述假设了与mTOR相关的病毒、免疫和代谢途径之间的可能交集，以及IF可能改善临床成果的潜在机制。未来需要前瞻性随机对照临床试验来评估间歇性禁食（IF）方案，以预防和治疗人类中度至重度形式的COVID-19。
2）《如何杀死病毒增强免疫力，阻断病毒复制，自然疗法（柏格医生）》（哔哩哔哩2022-12-13）
（字幕摘录）断食让身体处于自噬状态。日常做间歇断食（只吃1～2餐），会清除体内许多病菌，身体会回收老旧的受损蛋白质、微生物、病菌。断食非常重要，特别要定期做长断食——断食48～72小时。断食直接清除体内休眠中病菌，并大大增强抵抗力。定期做长断食效果：创造新的免疫力，修复受损的免疫系统，可增强对微生物的抵抗力。断食是抗病毒的强大武器。
3）《杀死体内病原体9方法，增强抵抗力（柏格医生）》（哔哩哔哩2021-08-28）
（字幕摘录）断食也增强免疫力。动物生病时不吃东西，人生病会没食欲，是自然抗菌法。
4.1）《肠道菌群与免疫系统（柏格医生）》（哔哩哔哩2021-05-08）
（字幕摘录）70%的免疫系统就是肠道菌群。肠内周围有数万亿的微生物，这些菌群一直和你互动、交换。你提供菌群居所，菌群给你免疫保护、营养、帮助血糖各种好处。身体内外有1万多种的益菌。多数菌群在大肠的粘液层、粘液层上方。另外，大肠细胞有一层免疫细胞保护，有入侵者时，免疫细胞立即攻击、吞噬入侵者。当身体菌群失衡时，会失去肠道淋巴层的菌群，也减少淋巴结、减少抗体。
因肠道菌群和免疫系统紧密相连，肠道菌群减少，会降低T细胞，且T细胞不能分辨好坏，身体对自己“开枪”，内部严重损害、发炎。身体具有这能力分辨数万亿细胞不是病原体，是那些合作紧密、对身体有益的益菌。身体还建立环境让有益菌存活着，不攻击或杀死有益菌。若肠道菌群不足，短链脂肪酸会减少，其中的丁酸盐有助血糖，改善胰岛素阻抗，还可改善免疫力。肠道菌不足，身体不能产生B12、B1、维生素K、生物素、乳酸（乳酸会让病原体不好存活）。同时，肠道菌群会囤积食物和空间也限制了病原体的存在。肠道菌群越少，肠壁的屏障越弱，导致肠漏症。
我的看法：自体免疫疾病起源于肠道。如果你与患有自体免疫疾病的人交谈，几乎都有肠道问题。我也有谈论COVID-19（冠状病毒），该病毒攻击细胞的方式是攻击ACE2的受体。很巧的，肠内比肺里有更多的ACE2受体。这是另类进入细胞的方式，不只是肺部感染而已。
4.2）《断食超级增加肠道微生物》（哔哩哔哩2021-05-06）
（字幕摘录）细菌在断食动物——老鼠、果蝇、虫身上活更久，增强抗氧化、增强抗外来压力（指暴露在化学物）。例如化疗后断食，体内免疫力的有益菌能活更久。断食让微生物多样化，降低坏细菌的损害力，恢复阳上皮（阳上皮是结肠的保护层）。断食饿死吃糖的酵母菌和念珠菌，杀死坏的微生物，帮助有益菌。有益菌做很多事，会回收与增加胆汁，胆汁消化脂肪、吸收脂溶性维他命、欧米茄3，制造丁酸盐，可降血糖、胰岛素阻抗的健康脂肪。微生物制造支链氨基酸（BCAA），有助于神经递质。有益菌制造维他命、排毒、消炎。要保护、支援这些有益菌，是做断食。
5）《伯格医生：教你如何应对新冠后遗症》（哔哩哔哩2023-01-05）
（字幕摘录）新冠后遗症，是指感染新冠病毒后，可能出现的残留症状。有些症状可能会持续数周甚至数月，这取决于感染的严重程度。病毒深入肺部了吗？形成疤痕组织了吗？最重要的是有没有预先存在的疾病，例如高血压、肥胖、心脏病和癌症，所有这些额外的因素都会延长康复周期。
新冠后遗症，排第一的是疲劳。第二个是呼吸急促，尤其是锻炼时。咳嗽、关节痛，还有胸痛，还可能有其他症状：抑郁症、头痛、反复发烧，丧失味觉或嗅觉，心脏砰砰跳动或心悸。有很多方法可以解决这个问题。
间歇性禁食，不要吃早餐，不要吃零食，吃的很少，一天两顿饭，甚至一天一顿饭。接下来会发生什么？你会增强你的免疫系统，你的免疫系统会变得更强。
6）《改善能量和修复脑雾的最佳方法 | 史蒂文·甘德里博士》（哔哩哔哩2022-10-11）
（字幕摘录）改善能量和脑雾的最佳方法。我的许多患者来找我时，说感到精力不足和疲劳。低能量的第一大原因是炎症。他们有的是肠漏和炎症，导致胰岛素抵抗。所以我首先推荐的事情，是你必须照顾好你的肠道健康，让你的能量水平恢复。
几年前我们知道，肠道中有神经与大脑交流，这就是“肠道—大脑连接”这个词。事实上，你的肠道周围的神经细胞比整个脊髓中的神经元多，这就是为什么许多人称肠道为第二个大脑。但更重要的是，还有第三个组成部分，这就是微生物组。肠道—大脑连接，以及我们归因于神经元的许多事情，是微生物组与大脑对话。减少饮食中的糖分，糖会滋生肠道中的有害细菌，而有害细菌会刺激肠道周围的白细胞发炎。
第二个技巧：限制你的饮食窗口。这个实际上是我发现和其他人发现的最好方法之一。间歇性禁食或禁食窗口，限制时间控制。禁食最初很难做到，因为大多数胰岛素抵抗的人都坚持说当他们停止进食时他们的脸是扁的。所以诀窍是逐渐接近这个。如果你下周早上七点吃早餐，我们将在八点吃早餐，只等一个小时。下周周末休假，我们将在早上9点吃早餐。我们将在一周内这样做。我们将在周末休息，所以每周我们会在开始第一餐的时间增加一个小时，你会在五周后感到惊讶：你在中午吃早饭。这是降低胰岛素抵抗、获得新陈代谢灵活的最简单的最佳方法之一。
第三件事：睡眠。睡眠真正让你的大脑经历一个清洁周期，清理毒素和积累的毒物。你必须有大量的血液流向你的大脑才能完成这一点。所以诀窍是，如果在接近睡觉的时间吃东西，从你的心脏流出的血液流向你的肠道以消化你吃的食物，而没有那么多的血液流向你的大脑。所以简单的规则是在三个小时内不要吃东西。当你不吃东西时，你上床睡觉也会延长你的进食窗口，让你的大脑有机会清理。除非你有一个夜间修复、停机时间来清理你的线粒体和清理你的大脑，否则你可以做到所有其他技巧，你仍然可能筋疲力尽，而且现在还有脑雾。
｛编者注：虽然欧美医界讲断食法的资料海量，但目前只看到个别欧美医界人员少量谈及断食法防治“新冠”，且只是理论上谈，未见有实例试验研究。但愿有人做试验研究并发布科研成果，或许此法能高效防治全球“新冠”疫病。｝
【英文版】
Doctors in Europe and the United States discuss fasting therapy to prevent COVID-19
(20230110)
1) Is there any role of intermittent fasting in the prevention and improving clinical outcomes of COVID-19?Intersection between inflammation, mTOR pathway, autophagy and calorie restriction (Martin Gnoni)(NCBI 2021-06-04)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177033/
(Abstract) The coronavirus disease 2019 (COVID-19) pandemic is provoking a global public health crisis. Even though the academic world is intensively pursuing new therapies, there is still no “game changer” in the management of COVID 19. The Mammalian Target of Rapamycin (mTOR) is an ancient signaling system that has been proposed as a molecular tool used by coronaviruses and other RNA and DNA viruses in order to replicate and persist in the host cell. In recent years, Intermittent Fasting (IF), a practice consisting on a strict calorie restriction during a prolonged period of time during the day, has gained popularity due to its potential benefits in multiple health systems and in regulating inflammation. IF inhibits the mTOR pathway which is similar to the effects of Rapamycin in some animal models. mTOR inhibition and promotion of autophagy could potentially be the link between the possible direct benefits of IF in COVID-19 due to the interruption of the viral cycle (protein synthesis). Besides, IF has shown to be a strong anti-inflammatory in multiple prior studies, and may play a role in attenuating COVID -19 severity. This review hypothesizes the possible intersection between viral, immunological, and metabolic pathways related to mTOR and the potential mechanisms through which IF may improve clinical outcomes. Future prospective randomized controlled clinical trials to evaluate intermittent fasting (IF) regimens in order to prevent and treat moderate to severe forms of COVID-19 in humans are needed.
2) How to kill the virus to boost immunity, block virus replication, natural treatment (Dr. Berg)(BiliBili 2022-12-13)
(Extract) Fasting puts the body in a state of autophagy. When you do regular intermittent fasting (eating only one or two meals), you are cleaning up a lot of microorganisms in your body. Your body recycles old damaged proteins as well as microorganism, pathogens. Fasting is very important, especially periodic long fasting — 48 to 72 hours. Because it will not only directly remove some dormant pathogens in your body, but also strengthen your immune system. If you do regular periodic long fasting, you can basically create a new immune system, repair damaged immune system, strengthen your resistance against microorganisms. So it is a powerful weapon against the virus.
3) 9 Ways to Kill Pathogens in Your Body and Build Up resistance (Dr. Berg)(BiliBili 2021-08-28)
(Extract) Intermittent fasting also boosts immunity. When a animal get sick, they stop eating. If you get sick, you will lose your appetite. This is a natural way to a fight with pathogene.
4.1) Intestinal Microbiome and the Immune System (Dr. Berg)(BiliBili 2021-05-08)
(Extract) 70% of your immune system is your gut flora. The gut is surrounded by trillions of microbes in your body that contact and exchange with you. You give them a place to live. They give you immune protection, nutrition and other benefits. There are more than 10,000 kinds of beneficial bacteria inside and outside the body. Most of the microbes in your body live in the large intestine mucous layer, and above the mucous layer. In addition, the cells of the large intestine are protected by another layer of immune cells, which immediately attack and engulf the invader.When the body flora is out of balance, the flora of the intestinal lymph layer will be lost, and the lymph nodes and antibodies will be reduced.
Because intestinal flora is closely linked to the immune system, the reduction of intestinal flora will reduce T cells, and T cells can not distinguish good from bad, and the body “shoots” itself, causing serious internal damage and inflammation. The body has the ability to tell the trillions of cells that they are not pathogens, which are beneficial bacteria that work closely and are beneficial to the body. The body also sets up the environment for the beneficial bacteria to live without attacking or killing them. When gut flora is low, short-chain fatty acids are reduced, and butyrate helps blood sugar, improves insulin resistance, and improves immunity. If the intestinal bacteria are insufficient, the body can not produce B12, B1, vitamin K, biotin, and lactic acid (lactic acid will make it difficult for pathogens to survive). At the same time, gut bacteria hoard food and space, limiting the exsitence of pathogens. The lower the gut flora, the weaker the barrier, leading to leaky gut.
My opinion: autoimmune diseases originated in the gut. If you talk to people with autoimmune diseases, almost everyone have bowel problems. I’ve also talked about COVID-19, which attacks cells by attacking ACE2 receptors. As it happens, the intestine has more ACE2 receptors than the lungs. It’s an different way to get into cells, not just a lung infection.
4.2) Fasting greatly increases gut microbes (BiliBili 2021-05-06)
(Extract) Bacteria live longer in the animals that have a fasting — mice, fruit flies, worms — and increase their antioxidant capacity and resistance to foreign stress(exposure to a chemical). For example, fasting after chemotherapy, the beneficial bacteria in the body can live longer. Fasting diversifies microbes, reduces the damage caused by bad bacteria, and restores the positive epithelium (the protective lining of the colon). Fasting makes saccharomyces and candida starve to death, kills the bad microbes and helps the beneficial bacteria. Beneficial bacteria have many functions. They recycle and increase bile, which digests fat, absorbs fat-soluble vitamins, omega 3, and makes butyrate, a healthy fat that lowers blood sugar and insulin resistance. Microbes make branched chain amino acids (BCAA) that help neurotransmitters. Beneficial bacteria make vitamins, detoxify, and reduce inflammation. To protect and support these beneficial bacteria, it is necessary to do fasting.
5) Dr. Berg: How do you deal with the after-effects of COVID-19 (BiliBili 2023-01-05)
(Extract) After-effects of COVID-19 refers to the residual symptoms that may occur after infection with the novel coronavirus. Some symptoms may last for weeks or even months, depending on the severity of the infection. Has the virus penetrated deep into the lungs? Did it form scar tissue? The most important thing is that there are no pre-existing conditions, such as high blood pressure, obesity, heart disease and cancer, all of which are additional factors that prolong the recovery period.
As for after-effects of novel coronavirus,fatigue tops the list. The second is shortness of breath, especially during exercise. Cough, joint pain, and chest pain. There may also be other symptoms: depression, headache, recurrent fever, loss of taste or smell, pounding heart or palpitations. There are many ways to solve this problem.
Intermittent fasting, don’t eat breakfast, don’t eat between meals. Eat less, two meals a day, even one meal a day. What will happen next? You’ll boost your immune system, and your immune system will get stronger.
6) The best way to improve energy and repair brain fog | Dr Steven Delhi (BiliBili 2022-10-11)
(Extract) The best ways to improve energy and brain fog. Many patients come to me with feelings of low energy and fatigue. The number one cause of low energy is inflammation. Some of them have leaky gut and inflammation, leading to insulin resistance. So what are the things that I recommend first and foremost you’ve got to take care of your gut health, to get your energy levels back.
Years ago we knew that there were nerves in the gut that communicated to the brains and that’s where the word gut-brains connection from. In fact, nerve cells more neurons surrounding in your gut than are in your entire spinal. That’s why many people call gut is the second brain. More importantly, the third component to the gut brain connection is the microbiome. Many of the things we attribute to neurons are the microbiome talking to the brain. Cut out sugar in your diet. Sugar will breed harmful bacteria in your gut and harmful bacteria stimulate inflammation in the white blood cells surrounding the gut.
Second: restrict your eating window. This is actually one of the best ways that I’ve found and others have found to make yourself more flexible opposed to insulin resistance. Intermittent fasting or eating window. Restriction time controlled eating is initially hard to do because most people who are insulin resistant fall flat on their face when they stop eating. So the trick is to get closer to this gradually. If you have breakfast at 7 am next week, we will have breakfast at 8 am and wait only one hour. We have a holiday next weekend and will have breakfast at 9 am. We will do so in a week. We’ll have weekends off, so every week we’ll add an hour to the time it takes to start our first meal, and you’ll be surprised in five weeks.
Third: sleep. Sleep really lets your brain go through a cleansing cycle, clearing out toxins and accumulated poisons. There must be a lot of blood flow to your brain to accomplish this. So the trick is, if you eat near bedtime, the blood from your heart flows to your gut to digest the food you eat, and not as much blood flows to your brain. So the simple rule is don’t eat in three hours before going to bed. Going to bed when you’re not eating also extends your eating window, giving your brain a chance to clean up. Unless you have a overnight repair, downtime to clean out your mitochondria and clean out your brain, you can do all the other tricks and you still might be exhausted and there is still brain fog right now.
{Editor’s note: Although there is a large amount of data on fasting therapy by the European and American medical circles, only a few doctors in the European and American medical circles have talked about the prevention and treatment of COVID-19 by the fasting therapy, and they only talk about it theoretically, without any case study. Hopefully, someone will do a trial study and publish the results, perhaps this method can effectively prevent and cure the global COVID-19 disease.}